APPLICATION INFRASTRUCTURE
Simulations Plus | January 16, 2023
Simulations Plus, Inc. recently announced that its DILIsym Services (DSS) division released DILIsym® version X (DSX) Beta, the latest iteration of its flagship quantitative systems toxicology (QST) software for predicting and investigating drug-induced liver injury (DILI).
DILIsym modeling aids vital drug development decisions by prevising the potential DILI risk of new drug candidates. The modeling also identifies the biochemical events that contribute to DILI caused by a medicine and can thus predict specific subgroups of patients who are more likely to get DILI from that drug.
DILIsym modeling information helps guide go/no-go decisions on big drug development projects, potentially averting the terrible financial impacts of failed clinical trials or better offering reassurance that DILI will not be an insurmountable barrier to FDA approval. Over the past 12 years, the DILIsym Services division has coordinated the DILI-sim Initiative, a public-private partnership that helped guide the development of the DILIsym software package.
Some of the substantial updates for DSX include:
A complete software redesign that includes command line and graphical interface options and server/cloud computing capability (HPGL)
Four new exemplar compounds included with varying clinical presentations:
PF-04895162 (Generaux 2019)
Efavirenz
Anastrozole
Tamoxifen
Two new SimCohorts that include variability in susceptibility to liver injury and biomarker-related parameters (ALT and bilirubin)
About Simulations Plus
Simulations Plus, Inc. is a leading drug discovery/development software developer and preclinical and clinical pharmacometric consulting services provider for regulatory submissions and quantitative systems pharmacology models for drug-induced liver, kidney, and nonalcoholic fatty liver disease. Its software is licensed and applied to drug research by major pharmaceutical, biotechnology, chemical, and consumer goods companies as well as regulatory agencies worldwide. With its subsidiaries, Cognigen, DILIsym Services, and Lixoft, Simulations Plus offers solutions that bridge machine learning, physiologically based pharmacokinetics, quantitative systems pharmacology/toxicology, and population PK/PD modeling approaches.
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HYPER-CONVERGED INFRASTRUCTURE
euNetworks | March 14, 2023
euNetworks Group Limited, a company that provides bandwidth infrastructure in Western Europe, recently announced its acquisition of the dark fiber business branch of a utility company called ‘the Business Branch’ in Belgium.The Business Branch, constructed in the late 1990s, is a duct-based network with 1,660 km of fiber dispersed throughout unique Brussels routes and long haul routes across Belgium. It has access to additional high-bandwidth sites and is close to 13 data centers.
Customers from national and regional ISPs to content, cloud providers, mobile network operators, and hyperscalers will receive dark fiber and lit services through euNetworks' long-haul infrastructure. The recent upgrade underwent increased expansion capacity and ability to pull the new, higher-count cable, satisfying euNetworks' client bandwidth growth needs.
Paula Cogan, Chief Executive Officer of euNetworks remarked, “euNetworks continues to distinguish itself in the digital infrastructure ecosystem, delivering critical internet infrastructure to customers through an asset-rich business focused on developing and deepening its fibre networks in Europe.” She added, “This acquisition will strengthen euNetworks’ leadership in European infrastructure by enabling us to expand across Belgium while maintaining our focus on delivering unique and scalable network routes to our customers between key data centres. It also presents compelling investment opportunities as we look into adjacent geographies with our customers to give them an end-to-end experience and as we focus on the ongoing densification of the high-demand bandwidth region of FLAP (Frankfurt, London, Amsterdam and Paris).”
(Source – Business Wire)
The inclusion of the Business Branch complements euNetworks' current approach. euNetworks is committed to providing high-bandwidth fiber connectivity within and between European cities, constantly improving its infrastructure. These improvements include creating new routes, adding new paths, and expanding into key hyperscale data center sites, network aggregation points and data center clusters. These investments drive the capacity needs of euNetworks' customers and fuel the company's expansion.
About euNetworks
euNetworks was started in 2002 and has been serving wholesale, finance, content, media, mobile, data centers, and enterprise customers with critical bandwidth infrastructure services. The company owns and runs 17 fiber-based metropolitan networks and a high-capacity intercity backbone that connect 53 cities in 17 European countries. euNetworks offers a range of metropolitan and long-haul services, including Dark Fiber, Ethernet and Wavelengths and is a leading cloud connectivity provider.
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HYPER-CONVERGED INFRASTRUCTURE, APPLICATION INFRASTRUCTURE
H5 Data Centers | February 16, 2023
H5 Data Centers, a nationwide supplier of colocation and wholesale data center services, has announced the expansion of Southern Telecom into its Atlanta, Georgia, data center at 355 Courtland Street. Southern Telecom is one of the region's leading telecommunications providers. This low-latency fiber optic network extension will improve clients' service in Alabama, Georgia, Florida, and Mississippi.
H5 Data Centers, CEO Josh Simms, said, "The extension of Southern Telecom's fiber network to 345 Courtland Street strengthens our existing interconnection ecosystem." He added, "Our Atlanta data center supports access to unique long haul fiber routes, competitive metro fiber carriers, and one of the market's leading peering exchanges."
(Source – Businesswire)
Joe Patton, Southern Telecom BDM, stated, "We are excited to work with H5 and enable their customers to gain direct access to our robust network. This collaboration positively impacts Atlanta and other cities throughout the Southeast."
(Source – Businesswire)
H5 Atlanta Colocation Highlights:
110,000 SF data center in downtown Atlanta
High-capacity, redundant utility supplies from Georgia Power's modern power grid
Datacenter at the network's edge serves networks, content firms, and cloud service providers
Access to the leading metro fiber and communications providers in the area
Access for several carriers to 56 Marietta and 180 Peachtree
About H5 Data Centers
H5 Data Centers is one of the largest owners and operators of private data centers in the U.S., with over 3 million square feet of space. Its data center and facility solutions are developed and constructed to meet customers' business and operational needs. Currently, H5 Data Centers owns data centers in Ashburn, Atlanta, Cleveland, Cincinnati, Charlotte, Denver, San Luis Obispo, Phoenix, San Jose, and Seattle. The firm takes selecting a data center for your mission-critical workload seriously as a strategic choice. It recognizes the need for data center space that is both adaptable and expandable enough to accommodate both current and future demands.
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